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JTL-T-01
- Development stage
- Preclinical
- Lead developer
- JointechLabs
- Modality
- Hematopoietic Stem Cells → Adult Stem Cells → Stem Cell Therapies → Cell Therapies, Patient-derived iPSCs → iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies, Autologous CAR-T → CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Mesenchymal Stem Cells → Adult Stem Cells → Stem Cell Therapies → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intraarticular
01
Overview
JTL-T-01 is an investigational autologous, point-of-care regenerative therapy being developed for osteoarthritis that combines stromal vascular fraction (SVF) cells derived from a patient’s adipose (fat) tissue with an injectable scaffold to be administered intra-articularly. The product is designed to harness the regenerative and immunomodulatory properties of adipose-derived stem and progenitor cells together with the mechanical and lubricating benefits of a viscosupplement-like scaffold, with the aim of reducing pain and inflammation and slowing cartilage deterioration in osteoarthritic joints.[3][9] Developed by Jointechlabs, JTL-T-01 remains in the clinical development stage with supporting preclinical work funded in part by an NIH Small Business (SBIR) grant conducted in collaboration with Rush University.[3][9]
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