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JTR-161
- Development stage
- Discontinued
- Lead developer
- JCR Pharmaceuticals
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
JTR-161 is an allogeneic regenerative medicine product composed of mesenchymal stem cells derived from the dental pulp of healthy adult humans (DPCs). It was developed for the treatment of acute ischemic stroke (acute cerebral infarction). The therapeutic mechanism involves the intravenous administration of these stem cells, which are thought to exert neuroprotective effects, modulate the inflammatory response, and promote tissue repair in the brain following an ischemic event. The product was co-developed by JCR Pharmaceuticals and Teijin Pharma in Japan. However, in April 2022, the collaboration was terminated after a Phase 1/2 clinical trial failed to meet its primary efficacy endpoint, leading Teijin to return the development rights to JCR Pharmaceuticals.
- Other names
- human dental pulp mesenchymal stem cell injectionallogeneic dental pulp stem cells
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