juanbi

Juanbi is a traditional Chinese medicine (TCM) formula used primarily for the treatment of musculoskeletal pain and inflammatory conditions such as rheumatoid arthritis and osteoarthritis. The canonical form "Juanbi" refers to a family of related herbal formulas including "Juan Bi Tang" (Remitting Bi Decoction), "Juanbi Pill," and commercial products like "Juan Bi Formula." These formulas are designed to remove wind-dampness, disperse cold, eliminate joint painful obstruction, circulate Qi and blood, and relieve painful stasis according to TCM principles[1][2][5][7]. Modern pharmacological studies suggest that the mechanism involves inhibition of key inflammatory pathways such as activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB), reduction of pro-inflammatory cytokines like TNF-α and IL-1β[2][5][8], modulation of immune cell populations (reducing NK cells while boosting T cells)[2], downregulation of prostaglandin receptors in synovial tissue[2], relief from acute/chronic soft tissue inflammation[2], protection against bone destruction via modulation of ephrinB2 signaling[6], and improvement in quality-of-life measures for patients with chronic pain syndromes. The formula typically contains multiple herbs such as Notopterygium root/rhizome (Qiang Huo), Turmeric rhizome (Jiang Huang), White Mulberry twig (Sang Zhi), Angelica sinensis root (Dang Gui), Acanthopanax cortex/bark (Hong Mao Wu Jia Pi), Pubescent angelica root (Du Huo), Large leaf gentian root (Qin Jiao), Frankincense resin (Ru Xiang), Costus/Vladimiria root (Chuan Mu Xiang), Ligusticum wallichii rhizome/rootstock/Chuanxiong Rhizoma/Chuan Xiong, Cinnamon twig/Ramulus Cinnamomi/Gui Zhi, Chinese licorice/honey-fried Glycyrrhizae Radix Preparata/Zhi Gan Cao among others; specific composition may vary by manufacturer or modification[1][7]. It is administered orally in forms such as decoctions/granules/tablets/capsules.

Brand names

Juan Bi FormulaJuan Bi TangJuanbi PillJuanbi capsule

Other names

蠲痹汤Remitting Bi DecoctionJuan Bi TangJBT