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juanbi pill + methotrexate
- Development stage
- Unknown
- Lead developer
- 藥捷安康
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Juanbi pill + methotrexate is a combination therapy consisting of the traditional Chinese medicine Juanbi pill and the disease-modifying antirheumatic drug (DMARD) methotrexate. Juanbi pill is a herbal formula used in China for centuries to treat rheumatoid arthritis (RA), aiming to relieve joint pain and prevent joint malformation. Methotrexate is a folic acid antagonist that inhibits nucleotide synthesis, suppressing inflammation and immune activity. The combination has been studied in randomized controlled trials for active rheumatoid arthritis, with evidence suggesting it may improve disease activity scores, reduce joint inflammation, protect against bone damage, and potentially reduce adverse reactions associated with methotrexate[1][2][3][4]. The primary indication for this combination is active rheumatoid arthritis.
- Other names
- juanbi pill combined with methotrexatejuanbi pill plus methotrexate
02
Targets
DHFR (Dihydrofolate reductase)
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