Drug intelligence / Profile preview

juhong tanke ye

Development stage
Unknown
Lead developer
Xiangxue Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Juhong Tanke Ye (橘红痰咳液) is a traditional Chinese medicine oral liquid formulation composed of eight herbal ingredients: Citrus grandis 'Tomentosa' (化橘红), Stemona japonica (百部, honey-fried), Pinellia ternata (半夏, processed), Cynanchum stauntonii (白前), Prunus armeniaca var. ansu seed (苦杏仁), Schisandra chinensis fruit (五味子), Poria cocos sclerotium (茯苓), and Glycyrrhiza uralensis root (甘草). It is used to regulate qi, resolve phlegm, moisten the lungs, and relieve cough. The primary indications are cough with copious sputum due to phlegm-dampness obstructing the lung, as seen in conditions such as acute and chronic bronchitis, upper respiratory tract infections including common cold and pharyngitis. Its mechanism of action involves multiple pathways including anti-inflammatory effects, modulation of β2 adrenergic receptor signaling for bronchodilation and antitussive effect, inhibition of NF-kappa B signaling for anti-inflammation, regulation of prostaglandin-endoperoxide synthase 2 activity for inflammation control, as well as effects on cholinergic synapses and calcium signaling pathways[7]. Key active constituents include naringin from Citrus grandis 'Tomentosa', amygdalin from bitter apricot kernel, glycyrrhizic acid from licorice root[7]. The product is typically administered orally.

Brand names
香雪橘红痰咳液橘山牌橘红痰咳液
Other names
橘红痰咳液Juhong Tanke YeZuoHongTanKeYe
02

Targets

RELA (Nuclear Factor Kappa B Subunit p65)EGFR (Epidermal growth factor receptor)TNFA (Tumor necrosis factor alpha (soluble))ADRB2 (β2)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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