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juhuashuxin
- Development stage
- Phase 2
- Lead developer
- Xiyuan Hospital
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Juhuashuxin is a botanical drug candidate developed by Xiyuan Hospital of the China Academy of Chinese Medical Sciences (CACMS) for the treatment of cardiovascular conditions, specifically angina pectoris and coronary heart disease. Formulated as an oral tablet, it is derived from traditional Chinese medicine (TCM) principles, likely utilizing *Chrysanthemum* species as a primary component. The drug has been evaluated in Phase 1 clinical trials (such as ChiCTR-IPR-15007224) to characterize its pharmacokinetic and pharmacodynamic profiles in healthy volunteers. Its therapeutic intent is to improve myocardial blood supply and alleviate symptoms of heart disease, potentially by modulating vascular endothelial function or coronary blood flow, although its specific molecular targets remain a subject of investigation.
- Brand names
- Juhuashuxin Tablet
- Other names
- Juhua Shuxin菊花舒心片
02
Targets
IL10 (Interleukin-10)IL-6 (Interleukin 6)MEKNF-κBNFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)TLR4 (Toll-like receptor 4)TNFA (Tumor necrosis factor alpha (soluble))
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