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JunB shRNA
- Development stage
- Preclinical
- Lead developer
- National Center for Tumor Diseases Heidelberg
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
JunB shRNA is a gene-silencing therapeutic candidate primarily utilized in preclinical research to investigate the role of the AP-1 transcription factor JunB in multiple myeloma (MM). Delivered via viral vectors such as pLKO.1 or inducible Tet-systems, this short hairpin RNA (shRNA) specifically targets and reduces the expression of JunB. In the bone marrow microenvironment, JunB is induced by soluble factors like IL-6 and promotes MM cell proliferation, survival, and resistance to standard therapies like dexamethasone and bortezomib. By knocking down JunB, the expression of downstream pro-survival targets such as Mcl-1 and c-Myc is downregulated, leading to inhibited tumor growth and sensitized cancer cells to chemotherapy.
- Other names
- JunB short hairpin RNA
02
Targets
JUNB (Transcription factor JunB mRNA)
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