juniperus osteosperma pollen

Juniperus osteosperma pollen is a biological allergen extract derived from the Utah Juniper tree, a significant source of seasonal respiratory allergies in the Western United States. It is clinically utilized for both the diagnosis of IgE-mediated hypersensitivity and for allergen-specific immunotherapy (ASIT). In diagnostic applications, such as skin prick or intradermal testing, the extract cross-links allergen-specific IgE on the surface of mast cells and basophils, triggering the release of histamine and other inflammatory mediators that result in a localized wheal-and-flare reaction. For therapeutic purposes, the extract is administered in escalating doses to induce immunological tolerance. This process involves modulating the immune system to shift from a pro-inflammatory Th2 cytokine profile to a Th1-mediated response, expanding regulatory T cell (Treg) populations, and stimulating the production of allergen-specific IgG4 blocking antibodies that compete with IgE for allergen binding.

Brand names

Utah Juniper Pollen Extract

Other names

Utah Juniper pollenJuniperus utahensis pollen