Drug intelligence / Profile preview

JV-1-36

Development stage
Preclinical
Modality
Small Molecules, Peptides
Administration
Unknown
01

Overview

JV-1-36 is a synthetic peptide **antagonist of growth hormone-releasing hormone (GHRH)**. It inhibits GHRH receptor signaling, which is implicated in cancer cell growth, proliferation, and survival. JV-1-36 reduces reactive oxygen species (ROS) production and has demonstrated anti-proliferative, anti-inflammatory, and anti-oxidative activities in preclinical studies, notably in A549 lung cancer and endometriotic cells. This mechanism makes GHRH antagonists like JV-1-36 promising for experimental cancer and endometriosis therapies. JV-1-36 is not approved for any clinical indication and is primarily used in research settings[3][4][1].

Other names
JV-1-36JV1-36JV 1-36
02

Targets

GHRHR (Growth hormone-releasing hormone receptor)

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