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JV-213

Development stage: Unknown
Lead developer: University of Texas MD Anderson Cancer Center
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

JV-213 is an investigational autologous chimeric antigen receptor (CAR) T cell therapy that targets CD79b, a component of the B-cell antigen receptor complex. It is designed to treat adults with relapsed or refractory B-cell lymphomas by engineering a patient's own T cells to express a CAR specific for CD79b. Upon administration, these modified T cells selectively bind to and induce cytotoxicity in CD79b-expressing tumor cells. The therapy is currently being evaluated in phase 1 clinical trials for safety, tolerability, and preliminary efficacy. This is the first-in-human study of this product and it has not yet been approved or commercially released[1][2][3][4][5][6][8][9].

Other names: autologous anti-CD79b CAR T cells JV-213

Targets

B-cell antigen receptor complex-associated protein beta chain

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