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JW-C2
- Development stage
- Preclinical
- Lead developer
- Juventas Cell Therapy
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
JW-C2 is an autologous chimeric antigen receptor (CAR) T-cell therapy being developed by Juventas Cell Therapy for the treatment of solid tumors, specifically breast cancer. The therapy is engineered to dual-target the disialogangliosides GD2 and GD3, which are oncogenic antigens frequently overexpressed in breast cancer cells. By utilizing a dual-targeting strategy, JW-C2 aims to overcome tumor heterogeneity and reduce the likelihood of antigen escape, thereby enhancing the durability and efficacy of the anti-tumor immune response. It is part of Juventas' broader pipeline of innovative cellular products targeting both hematological and solid malignancies.
- Other names
- GD2/GD3-targeting CAR-T cell therapyJuventas GD2/GD3 CAR-T
02
Targets
GD2GD3 (Ganglioside GD3)
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