Drug intelligence / Profile preview

JWATM213

Development stage
Unknown
Lead developer
JW Therapeutics
Modality
CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

JWATM213 is an autologous chimeric antigen receptor T-cell (CAR-T) therapy targeting alpha-fetoprotein (AFP), developed by Shanghai Ming Ju Biotechnology, a subsidiary of JW Therapeutics. Currently in Phase 1 clinical development, it is designed for the treatment of hepatocellular carcinoma (HCC). The therapy utilizes T cells engineered to recognize AFP-derived peptides presented by HLA-A*02:01 on the surface of tumor cells. By targeting AFP, a protein frequently overexpressed in HCC, JWATM213 aims to provide a precision immunotherapy option for patients with advanced liver cancer who have limited treatment alternatives.

02

Targets

Alpha-fetoprotein-derived peptide presented by Human Leukocyte Antigen class I

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