Drug intelligence / Profile preview

JY207b

Development stage
Preclinical
Lead developer
Shenzhen Enduring Biotech
Modality
Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
01

Overview

JY207b: sourced facts only. name: "Meanwhile, JY207b could still preferentially bind to CD47/PD-L1 double positive tumor cells, thus reducing the possibility of on-target toxicities." [DOI:10.1158/1538-7445.am2024-3126]; target: "Meanwhile, JY207b could still preferentially bind to CD47/PD-L1 double positive tumor cells, thus reducing the possibility of on-target toxicities." [DOI:10.1158/1538-7445.am2024-3126]; target: "Meanwhile, JY207b could still preferentially bind to CD47/PD-L1 double positive tumor cells, thus reducing the possibility of on-target toxicities." [DOI:10.1158/1538-7445.am2024-3126]; developer: "1Shenzhen Enduring Biotech, Ltd., Shenzhen, China." [DOI:10.1158/1538-7445.am2024-3126]; modality: "A novel pegylated bispecific antibody-drug conjugate (P-BsADC) JY207b targeting cancers co-expressing PD-L1 and CD47" [DOI:10.1158/1538-7445.am2024-3126]; stage: "In CDX models and a PDX model of transplanted tumor tissues from lung cancer patients, the compound JY207b demonstrated strong tumor inhibition efficacies at low doses." [DOI:10.1158/1538-7445.am2024-3126]

02

Targets

CD274 (Programmed cell death protein 1 ligand 1)CD47 (Cluster of Differentiation 47)

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