K-00546

K-00546 is an experimental small molecule inhibitor targeting cyclin-dependent kinases 1 and 2 (CDK1 and CDK2), with reported IC50 values of 0.6 nM for CDK1 and 0.5 nM for CDK2[2][4]. It also inhibits CDC-like kinases CLK1 and CLK3[4]. The compound demonstrates marked antiproliferative activity in preclinical studies and is being investigated primarily as an anticancer agent due to its ability to disrupt cell cycle progression by inhibiting key serine/threonine-protein kinases involved in mitosis[1][4]. Its chemical formula is C15H13F2N7O2S2.

Other names

5-amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide