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K8 Implant
- Development stage
- Unknown
- Lead developer
- Inflammasome Therapeutics
- Modality
- Small Molecules
- Administration
- Intravitreal, Implant
01
Overview
K8 Implant is a sustained-release intravitreal implant containing a small molecule inhibitor of the NLRP3 inflammasome, developed by Inflammasome Therapeutics. It is currently in clinical development for the treatment of Geographic Atrophy (GA), the advanced stage of dry age-related macular degeneration. The mechanism of action involves the inhibition of NLRP3 inflammasome activation, which subsequently prevents the production and activity of the pro-inflammatory cytokines interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). By targeting these pathways, the K8 Implant aims to reduce the chronic neuroinflammation and retinal pigment epithelial cell death associated with GA progression.
- Other names
- K8K-8K 8
02
Targets
IL18 (Interleukin-18)IL1B (Interleukin-1 beta)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)
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