kaempferia parviflora extract

Kaempferia parviflora extract is a standardized herbal extract derived from the rhizome of *Kaempferia parviflora*, commonly known as black ginger, a plant in the Zingiberaceae family[1][3][5]. The extract is rich in polymethoxyflavones (notably 5,7-dimethoxyflavone, 5,7,4'-trimethoxyflavone, and 3,5,7,3',4'-pentamethoxyflavone)[1][3]. Its mechanism of action is multifaceted: - **Anti-inflammatory**: Inhibits cytokine expression, downregulates COX2 and PGE2 synthesis, and suppresses MAPK and STAT signaling[3]. - **Antiobesity**: Activates brown adipose tissue (BAT) thermogenesis, increases whole-body energy expenditure, and reduces visceral and subcutaneous fat[3][5]. - **Antioxidant**: Scavenges free radicals and enhances endogenous antioxidant capacity[3]. - **Vascular relaxation**: Promotes vasodilation through endothelial mechanisms supporting physical fitness[2][3]. - **Reproductive health**: Shown to improve erectile function and male reproductive parameters in clinical studies[3]. - **Other studied properties** include anticancer (only in vitro), antimicrobial, neuroprotective, anti-aging, and metabolic regulation[3]. Pharmacokinetic studies indicate rapid systemic absorption with low oral bioavailability, wide tissue distribution (primarily liver and kidney), and elimination largely via urine and feces as demethylated, sulfated, and glucuronidated metabolites[1]. Clinical studies have mainly evaluated oral supplementation for its safety, antiobesity, physical fitness, anti-inflammatory, and male reproductive benefits[3][4][5].

Brand names

SIRTMAXKPFORCEKaempMax

Other names

black ginger extractKP extract