kaempferide

**Kaempferide** is a naturally occurring O-methylated flavonol (a type of flavonoid) with the chemical formula C16H12O6. It is the 4′‑O‑methyl derivative of kaempferol and can be found in plants such as *Kaempferia galanga* (aromatic ginger), *Alpinia officinarum*, and others[1][2][9]. As a small molecule compound, kaempferide exhibits several biological activities including antioxidant, anti-inflammatory, anticancer (notably by inhibiting pancreatic cancer cell growth via blockade of an EGFR-related pathway), antihypertensive, antidiabetic effects and protection against myocardial ischemia/reperfusion injury through activation of the PI3K/Akt/GSK‑3β pathway[2][3][4][9]. It has also been reported to inhibit melanogenesis in vitro. Its mechanism involves modulation of multiple cellular signaling pathways relevant to oxidative stress and apoptosis. Currently it is considered an investigative or discovery agent rather than an approved pharmaceutical drug.

Other names

KaempferideKaempferid4'-Methylkaempferol4'-O-MethylkaempferolKaempferol 4'-methyl etherKaemperideCampherideKempferideUNII-508XL61MPDUNII508XL61MPDUNII 508XL61MPD4'-Methoxy-3,5,7-trihydroxyflavoneKAMPFERIDE3,5,7-Trihydroxy-(4-methoxyphenyl)-4H-chromen-oneEINECS 207–738–4