Drug intelligence / Profile preview

kaempferol + zinc

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Kaempferol + zinc is a combination or chelated complex consisting of the natural flavonol kaempferol and the essential trace element zinc. Kaempferol is a dietary flavonoid found in various plants, such as kale, tea, and broccoli, and is recognized for its antioxidant, anti-inflammatory, and potential antineoplastic properties. Zinc is a vital mineral that serves as a structural or catalytic cofactor for over 300 enzymes and is essential for immune function, DNA repair, and cellular metabolism. Research into the kaempferol-zinc complex suggests that the chelation of zinc by the flavonoid can enhance the biological efficacy and stability of both components. This combination is primarily investigated in preclinical studies for its synergistic effects in promoting bone health (osteogenesis), where it stimulates osteoblast differentiation and inhibits bone resorption, making it a candidate for the management of osteoporosis. Additionally, it has been studied for its ability to induce apoptosis in cancer cells and for its potential insulin-mimetic effects in diabetes research.

Other names
kaempferol-zinc complexkaempferol-zinc(II) complexzinc-kaempferol complex
02

Targets

ESR2 (ERβ)NF-κBCASP3 (Caspase-3)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)

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