Drug intelligence / Profile preview

KAKW

Development stage
Preclinical
Lead developer
East China University of Science and Technology
01

Overview

KAKW: sourced facts only. name: "The designed peptide KAKW exhibited a superior ACE inhibitory effect with IC50 of 2.02 ± 0.20 μM." [PMID:40153927]; target: "The designed peptide KAKW exhibited a superior ACE inhibitory effect with IC50 of 2.02 ± 0.20 μM." [PMID:40153927]; developer: "State Key Laboratory of Bioreactor Engineering, Department of Food Science and Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, 200237, PR China." [PMID:40153927]; stage: "KAKW could decrease 20 mmHg SBP at 4 h and 18 mmHg DBP at 6 h during the acute trial of spontaneously hypertensive rats (SHRs), compared to that Lisinopril dropped 33 mmHg SBP and 28 mmHg DBP at 2 h." [PMID:40153927]

02

Targets

ACE (Angiotensin Converting Enzyme)

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