kalkitoxin thiol amide

Kalkitoxin thiol amide (KTA) is a lipopeptide derivative and synthetic intermediate of kalkitoxin, a natural toxin originally isolated from the marine cyanobacterium *Moorena producens* (formerly *Lyngbya majuscula*). Kalkitoxin thiol amide is being investigated for its potential therapeutic applications in oncology and bone health. It has been shown to suppress breast cancer cell proliferation, migration, and invasion, and to inhibit breast cancer metastasis to the bone and brain in preclinical models. Additionally, kalkitoxin thiol amide inhibits RANKL-induced osteoclast differentiation, thereby preventing bone destruction and inflammatory bone loss.