Drug intelligence / Profile preview

kangai injection

Development stage
Unknown
Lead developer
Jilin Changbaishan Pharmaceutical Group
Administration
Intravenous
01

Overview

**Kangai injection** is an intravenous multi-herb traditional Chinese medicine product developed and manufactured by Jilin Changbaishan Pharmaceutical Group. It contains botanical extracts derived from Astragalus membranaceus, Panax ginseng, and Sophora flavescens, with measurable circulating constituents including oxymatrine, matrine, astragaloside IV, and several ginsenosides. It is a China-approved adjunctive treatment used alongside anticancer therapy, particularly for lung cancer, primary liver cancer, and rectal cancer; published meta-analyses have evaluated its use with platinum chemotherapy in advanced non-small cell lung cancer. ([sciencedirect.com](https://www.sciencedirect.com/science/article/pii/S0944711322001660))\n\nKangai injection does not have a single defined molecular target. Experimental studies suggest antiproliferative and immunomodulatory effects that may involve suppression of interleukin-6 and STAT3 signaling, as well as modulation of TNFR2, PI3K, AKT, and NF-kappa-B pathway activity. These molecular findings are largely derived from cell-based and network-pharmacology studies and should not be interpreted as establishing direct, selective target engagement for the complete herbal formulation. ([link.springer.com](https://link.springer.com/article/10.1007/s11655-020-3265-6))

Brand names
Kang Ai injectionKangai InjectionKang'ai Injection
Other names
Kang-Ai injectionKang’ai injectionKAI康艾注射液
02

Targets

IL-6 (Interleukin 6)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TNFR2 (Tumor necrosis factor receptor superfamily member 1B)STAT3 (Signal Transducer and Activator of Transcription 3)

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