Kangguzengsheng

Kangguzengsheng (also known as Kangguzengsheng Pian or Kanggu Zengsheng Wan) is a traditional Chinese medicine formula used primarily for the treatment of musculoskeletal conditions such as hyperostosis, hypertrophic spondylitis, cervical spondylosis, heel spurs, and proliferative arthritis[1][2][8]. The formulation consists of multiple herbal ingredients including Radix Rehmanniae Preparata, Herba Cistanches (steamed), Rhizoma Cibotii (processed with salt), Fructus Ligustri Lucidi (processed with salt), Herba Epimedii, Caulis Spatholobi, Semen Raphani (stir-baked), Rhizoma Drynariae, and Radix Achyranthis Bidentatae[8]. Its mechanism of action involves modulation of several biological pathways related to inflammation and bone metabolism. Network pharmacology and molecular docking studies suggest that active components in the formula interact with targets such as Estrogen receptor 1 (ESR1), Interferon gamma (IFNG), Interleukin-1 beta (IL1B), Nuclear factor kappa B subunit 1 (NFKB1), and Tumor necrosis factor (TNF)[3][4]. These interactions are believed to alleviate symptoms by influencing inflammatory signaling pathways like IL-17 and TNF pathways. The product is approved for use in China for skin and musculoskeletal diseases—specifically hyperostosis—and is manufactured by companies such as Fuzhou Minhai Pharmaceutical[2].

Brand names

Kangguzengsheng PianKanggu Zengsheng Wan

Other names

Kangguzengsheng TabletsKGZST