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Kangxian Huanji Granule (KXHJ) is a compound traditional Chinese medicine (TCM) formulation developed as an adjunctive therapy for the treatment of acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). As a multi-component herbal preparation, it is designed to address the complex pathophysiology of pulmonary fibrosis, which in TCM theory often involves patterns of lung-qi deficiency and blood stasis. Clinical trials, including randomized, double-blind, placebo-controlled studies, have evaluated KXHJ as an add-on to standard care (such as corticosteroids or pirfenidone) to improve clinical symptoms, stabilize lung function, and potentially reduce mortality associated with acute exacerbations. The drug is administered in granule form and represents a botanical approach to modulating inflammatory and fibrotic pathways in the lung.
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