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KarX-MR
- Development stage
- Phase 1
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
KarX-MR (BMS-986519) is an investigational modified-release formulation of xanomeline, a small molecule muscarinic acetylcholine receptor agonist that preferentially targets the M1 and M4 receptor subtypes. Developed by Karuna Therapeutics (now Bristol Myers Squibb), KarX-MR is designed to optimize the pharmacokinetic profile of xanomeline, potentially improving tolerability and reducing gastrointestinal side effects compared to immediate-release formulations. Xanomeline's activation of central M1 and M4 receptors is being explored to address cognitive and behavioral symptoms in neuropsychiatric and neurodegenerative conditions, including Alzheimer's disease and autism spectrum disorder. KarX-MR is currently being evaluated in Phase 1 clinical trials to compare its bioavailability, food effects, and safety profile against other xanomeline formulations.
- Other names
- xanomeline modified releasexanomeline mr
02
Targets
M1 (Muscarinic acetylcholine receptor M1)CHRM4 (M4)
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