Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
KB104
- Development stage
- Preclinical
- Lead developer
- Krystal Biotech
- Modality
- Viral Vectors → Gene Addition/Replacement → Gene Therapies, Gene Silencing → Gene Therapies, Gene Editing → Gene Therapies
- Administration
- Topical, Injectable
01
Overview
KB104 is a herpes simplex virus type 1 (HSV-1) vector-based gene therapy developed by Krystal Biotech for the treatment of Netherton syndrome, a rare genetic skin disorder. The therapy is engineered to deliver a functional copy of the SPINK5 gene directly to the skin of patients with mutations in this gene, aiming to restore normal skin barrier function. The underlying technology platform is STAR-D, which enables targeted delivery and expression of therapeutic genes in affected tissues. As of early 2024, KB104 remains in preclinical development and has not yet entered clinical trials[1][2][8][9].
- Other names
- KB 104KB104KB-104
02
Targets
SPINK5 (Serine peptidase inhibitor Kazal-type 5)KLK5 (Kallikrein-related peptidase 5)
Beyond the preview
Go deeper on KB104.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on KB104.