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KB109

Development stage: Discontinued
Lead developer: Kaleido Biosciences
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Small Molecules, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

KB109 is a novel Microbiome Metabolic Therapy (MMT™) developed by Kaleido Biosciences. It is a synthetic glycan designed to modulate the structure and function of the gut microbiome to influence the host immune system and metabolic processes. KB109 was primarily investigated for the treatment of mild-to-moderate COVID-19, where it aimed to reduce the duration of symptoms and prevent complications by managing the inflammatory response. It was also being explored for chronic obstructive pulmonary disease (COPD) and for reducing the colonization of multi-drug resistant organisms in the gastrointestinal tract. However, development was halted when Kaleido Biosciences ceased operations in 2022.

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