KCKT-C

KCKT-C is an in situ transformable, acid-responsive nanoparticle designed for sonodynamic therapy (SDT) and mitochondrial-targeted cancer treatment. It is composed of a peptide-based framework (typically containing the sequence Lys-Cys-Lys-Thr) and the sonosensitizer Chlorin e6 (Ce6). In the acidic environment of cancer cell lysosomes, KCKT-C undergoes a morphological transformation from spherical nanoparticles into nanofibers. This transformation, coupled with the generation of reactive oxygen species (ROS) upon ultrasound irradiation, induces lysosomal membrane permeabilization, allowing the nanofibers to escape into the cytoplasm. The escaped nanofibers specifically aggregate around the mitochondria, where subsequent ultrasound treatment generates localized ROS, leading to irreversible mitochondrial damage. A key feature of KCKT-C is its ability to block protective autophagy; by causing lysosomal dysfunction, it prevents the cell from clearing the damaged mitochondria, thereby significantly enhancing the therapeutic efficacy of the oxidative stress.

Other names

KCKT-Ce6KCKT-Ce-6KCKT-Ce 6