Kebuzone

Kebuzone is a nonsteroidal anti-inflammatory drug (NSAID) of the pyrazolidinedione class, chemically related to phenylbutazone. It is primarily used for the treatment of inflammatory conditions such as thrombophlebitis and rheumatoid arthritis. Kebuzone acts mainly by inhibiting cyclooxygenase (COX) and lipoxygenase enzymes, thereby reducing the synthesis of prostaglandins and leukotrienes involved in inflammation via the arachidonic acid pathway. The drug has a long elimination half-life (70–100 hours), is excreted renally, and can be administered orally or intramuscularly. Its use has been associated with adverse effects including allergic reactions, gastrotoxicity, nephrotoxicity, local tissue necrosis at injection sites, and liver damage[1][2][4][5][6].

Other names

kebuzoneketophenylbutazonequebuzonaketazone