Drug intelligence / Profile preview

kefir

Development stage: Preclinical
Lead developer: Lifeway Foods
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Peptides, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Kefir is a probiotic fermented milk beverage created by inoculating milk with kefir grains, a symbiotic culture of lactic acid bacteria and yeasts. It is being clinically investigated for various health benefits, primarily acting as a microbiome modulator. Research suggests that regular consumption of kefir may improve several components of metabolic syndrome, including reducing blood pressure, triglycerides, and fasting glucose, while increasing HDL cholesterol. It has also demonstrated potential anti-inflammatory effects by decreasing levels of pro-inflammatory cytokines such as TNF-α and IFN-γ. The therapeutic mechanisms are attributed to both the live microorganisms that modulate the gut microbiota and the bioactive compounds produced during fermentation, such as exopolysaccharides (e.g., kefiran) and peptides with activities like angiotensin-converting enzyme (ACE) inhibition.

Other names: kefir

Targets

ACE (Angiotensin Converting Enzyme)NFKB1 (NF-κB1)

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