Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
ketamine + lidocaine + magnesium sulfate
- Development stage
- Unknown
- Lead developer
- Ain Shams University
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Ketamine + lidocaine + magnesium sulfate is an investigational combination therapy regimen being studied by researchers at Ain Shams University for use in opioid-free anesthesia (OFA). The protocol involves the intravenous infusion of these three agents to manage intraoperative bleeding and improve the quality of the surgical field during endoscopic nasal surgeries. Ketamine acts as an NMDA receptor antagonist, providing potent analgesia and maintaining hemodynamic stability. Lidocaine, a sodium channel blocker, offers systemic anti-inflammatory and analgesic effects. Magnesium sulfate functions as both an NMDA receptor antagonist and a calcium channel modulator, which helps in achieving controlled hypotension and reducing the requirement for volatile anesthetics. This triple-drug approach is designed to optimize surgical conditions while avoiding the side effects associated with traditional opioid-based anesthetic techniques.
- Other names
- ketamine/lidocaine/magnesium sulfate combinationopioid-free anesthesia (Ain Shams University)
02
Targets
NMDAR (Glutamate receptor ionotropic, NMDA)NaV (Voltage-gated sodium channels)CaV (Voltage-gated calcium channel protein complex)
Beyond the preview
Go deeper on ketamine + lidocaine + magnesium sulfate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ketamine + lidocaine + magnesium sulfate.