ketamine + propofol + lidocaine

A combination of **ketamine**, **propofol**, and **lidocaine** is used as an intravenous anesthetic and sedative regimen for procedural sedation and analgesia, particularly in surgical and interventional settings. - **Ketamine** is a dissociative anesthetic that acts primarily as an NMDA receptor antagonist, providing analgesia, amnesia, and maintaining airway reflexes and cardiovascular stability. - **Propofol** is a sedative-hypnotic agent acting mainly through potentiation of GABAergic transmission at the GABAA receptor, used for induction and maintenance of anesthesia, causing rapid onset and recovery but lacking inherent analgesic properties. - **Lidocaine** is a local anesthetic and antiarrhythmic agent that blocks voltage-gated sodium channels, decreasing nerve impulse conduction and providing local pain relief. This combination is designed to leverage the synergistic effects of all three drugs: propofol’s sedation and rapid recovery, ketamine’s analgesia and sympathetic stimulation (helping prevent hypotension and respiratory depression), and lidocaine’s reduction of injection pain and potential to reduce propofol-induced vascular discomfort. In clinical studies, this combination effectively provides sedation and analgesia during procedures, reduces propofol injection pain, and minimizes hemodynamic fluctuations and opioid requirements[1][3][5]. Used under strict supervision by medical professionals, this combination is not a commercially available fixed-dose product but is prepared for use in the operating room or procedural suite as needed.

Other names

KPLPFK