Drug intelligence / Profile preview

ketoanalogue amino acids

Development stage
Unknown
Lead developer
Fresenius Kabi
Modality
Small Molecules
Administration
Oral
01

Overview

Ketoanalogue amino acids (commonly marketed under the brand name Ketosteril) is a nutritional therapy and prescription drug product containing a mixture of essential amino acids and their corresponding nitrogen-free alpha-keto and alpha-hydroxy analogues. It is primarily used in combination with a protein-restricted diet (low-protein or very low-protein diet) to treat and delay the progression of chronic kidney disease (CKD) in the pre-dialysis phase. Following oral administration, the keto- and hydroxy-analogues are transaminated into their corresponding essential amino acids by utilizing endogenous nitrogen from non-essential amino acids (such as urea), thereby reducing the production and accumulation of toxic nitrogenous waste products (uremic toxins) while maintaining nutritional status and preventing protein-energy wasting.

Brand names
Alpha-KTAplazarKetoartKetologKetosterilNefrohealNefrosave KetoRenologValolog
Other names
alpha-ketoanaloguesalpha-ketoanalogues of essential amino acidsessential amino acids and ketoanaloguesketo acidsketo analogues of essential amino acidsketoanalogues of amino acids

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