Drug intelligence / Profile preview

Ketoconazole Cream

Development stage: Unknown
Lead developer: Janssen Pharmaceutica
Modality: Small Molecules
Administration: Topical

Overview

Ketoconazole Cream, marketed under brand names such as Jintaoning, is an antifungal medication used topically to treat various fungal skin infections. Its primary mechanism of action involves inhibiting the fungal cytochrome P450 enzyme 14α-demethylase, which is essential for the biosynthesis of ergosterol, a vital component of fungal cell membranes. By disrupting ergosterol synthesis, ketoconazole compromises the structural integrity and function of the fungal cell membrane, leading to increased permeability and ultimately fungal cell death. It is indicated for conditions such as tinea corporis, tinea pedis, tinea cruris, tinea versicolor, and cutaneous candidiasis.

Brand names: Jintaoning金达克宁
Other names: 酮康唑乳膏

Targets

CYP51A1 (Sterol 14α-demethylase)

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