Drug intelligence / Profile preview

Ketonate

Development stage
Unknown
Lead developer
Med Manor Organics
Modality
Small Molecules
Administration
Topical
01

Overview

Ketonate is a topical combination cream developed and marketed by Med Manor Organics. It contains three active ingredients: beclomethasone dipropionate (a synthetic corticosteroid), ketoconazole (a broad-spectrum antifungal), and neomycin (an aminoglycoside antibiotic). Ketonate is indicated for the topical management of mixed bacterial and fungal skin infections accompanied by inflammation, redness, and itching, such as infected eczema, dermatitis, athlete's foot, ringworm, and jock itch. The corticosteroid component reduces inflammation by inhibiting prostaglandin synthesis, the antifungal component disrupts fungal cell membrane synthesis, and the antibiotic component inhibits bacterial protein synthesis by binding to bacterial ribosomes.

Brand names
Ketonate
Other names
beclometasone + ketoconazole + neomycinbeclomethasone + ketoconazole + neomycinbeclomethasone dipropionate + ketoconazole + neomycin
02

Targets

Bacterial RibosomeGR (Glucocorticoid receptor)CYP51A1 (Sterol 14α-demethylase)

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