ketoprofen + baclofen + amitriptyline + lidocaine

This is a **compounded topical pharmaceutical formulation** combining four active ingredients: - **Ketoprofen** (a non-steroidal anti-inflammatory drug, NSAID) reduces pain and inflammation through inhibition of cyclooxygenase enzymes and prostaglandin synthesis. - **Baclofen** (a muscle relaxant and antispastic agent) acts primarily as a GABA-B receptor agonist, inhibiting spinal reflexes and reducing muscle spasticity or neuropathic pain. - **Amitriptyline** (a tricyclic antidepressant) inhibits reuptake of serotonin and norepinephrine, modulates pain transmission, and reduces neuropathic pain. - **Lidocaine** (a local anesthetic) blocks voltage-gated sodium channels, stabilizing neuronal membranes and reducing peripheral nerve pain. This combination is designed for topical use in the treatment of **chronic localized pain syndromes**—including neuropathic pain and musculoskeletal pain—where conventional therapies have failed or are poorly tolerated. This formulation is custom-compounded in compounding pharmacies; it is not a mass-produced, branded pharmaceutical.

Other names

ketoprofen + baclofen + amitriptyline + lidocaine