ketoprofen + isoniazid

This is a combination drug consisting of ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), and isoniazid, an antibiotic primarily used to treat tuberculosis. Ketoprofen acts by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), reducing prostaglandin synthesis and thereby decreasing inflammation, pain, and fever. Isoniazid works as a prodrug activated by the mycobacterial enzyme KatG; it generates reactive oxygen species that disrupt the mycobacterial cell wall, making it bactericidal against replicating Mycobacterium tuberculosis. The combination of these two drugs does not have a unique clinical indication or established use together but may be considered in rare cases where both anti-inflammatory and antimycobacterial effects are needed. Coadministration should be approached with caution due to potential additive hepatotoxicity[1][5].