Drug intelligence / Profile preview

ketorocaine lm kit

Development stage
Unknown
Lead developer
Asclemed USA
Modality
Small Molecules
Administration
Infiltration, Intramuscular, Intravenous, Topical
01

Overview

Ketorocaine LM Kit is an unapproved combination pharmaceutical kit developed by Asclemed USA for peri-procedural analgesia and local or regional anesthesia. It contains four small-molecule active ingredients: ketorolac tromethamine, lidocaine hydrochloride, bupivacaine hydrochloride, and povidone-iodine. The pharmacology reflects the combined actions of a nonsteroidal anti-inflammatory drug and local anesthetics: ketorolac reduces prostaglandin synthesis through cyclooxygenase inhibition, while lidocaine and bupivacaine block voltage-gated sodium channels to inhibit nerve impulse conduction; povidone-iodine serves as a topical antiseptic adjunct. Reported routes associated with the kit include infiltration, intramuscular, intravenous, and topical administration. Available context indicates that the product has not been found by the FDA to be safe and effective and that its labeling has not been approved.

Brand names
Ketorocaine LM Kit
Other names
ketorocaine lm kit
02

Targets

NaV (Voltage-gated sodium channels)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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