Drug intelligence / Profile preview

ketorolac + bupivacaine

Development stage
Unknown
Lead developer
Roche
Modality
Small Molecules
Administration
Intraarticular, Intraperitoneal
01

Overview

Ketorolac + bupivacaine is a combination of two drugs used primarily for perioperative and postoperative pain management. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-inflammatory properties, while bupivacaine is an amide-type local anesthetic that blocks nerve impulse conduction by inhibiting voltage-gated sodium channels. The combination leverages the rapid-onset local anesthesia of bupivacaine with the prolonged analgesic effect of ketorolac to provide enhanced pain relief after surgical procedures. Clinical studies have shown that this combination reduces postoperative pain scores, prolongs the duration of analgesia, decreases opioid requirements, and can be safely administered via various routes such as intra-articular or intraperitoneal injection[1][2][4][7].

Brand names
Marcaine
Other names
ketorolac + Light Marcaineketorolac + bupivacaineketorolac tromethamine + bupivacaine hydrochloride
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)SCN5A (Sodium channel protein type 5 subunit alpha)

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