ketorolac + ibuprofen

Ketorolac + ibuprofen is a combination of two nonsteroidal anti-inflammatory drugs (NSAIDs): ketorolac and ibuprofen. Both agents act by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Ketorolac is typically used for short-term management of moderate to severe pain, often postoperatively, while ibuprofen is widely used for mild to moderate pain and inflammation. Combining these two NSAIDs does not provide additional analgesic benefit but significantly increases the risk of serious adverse effects such as gastrointestinal bleeding, ulceration, kidney damage, and other NSAID-related toxicities. Clinical guidelines strongly advise against the concurrent use of ketorolac with other NSAIDs like ibuprofen due to these risks[1][2][7][9].

Brand names

ToradolAdvilMotrin

Other names

NSAIDsketorolacibuprofenNSAIDs-University of Colorado, Denver-postoperative pain