ketorolac + nefopam

Ketorolac + nefopam is a combination of two analgesic drugs used for the management of moderate to severe pain, particularly in postoperative settings. Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that exerts its effect primarily by inhibiting cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis and providing peripheral analgesia and anti-inflammatory effects. Nefopam is a centrally acting, non-opioid analgesic whose mechanism involves inhibition of monoamine reuptake (serotonin, norepinephrine, dopamine) and modulation of central pain pathways; it does not possess anti-inflammatory properties. The combination leverages the distinct mechanisms—peripheral action from ketorolac and central action from nefopam—to provide synergistic or additive analgesic effects while potentially reducing opioid requirements when used as part of multimodal pain management[1][4][5]. Studies suggest that this combination can offer effective postoperative pain control with an opioid-sparing effect[1][4].

Other names

ketorolac + nefopam