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keyhole limpet hemocyanin + ONO-4685

Development stage: Unknown
Lead developer: Ono Pharmaceutical
Modality: Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

ONO-4685 is an investigational anti-PD-1/CD3 bispecific antibody being developed for the treatment of relapsed or refractory T-cell lymphoma. It binds specifically to human PD-1 and CD3. PD-1 is an inhibitory receptor expressed on activated T and B cells, as well as on malignant T-cells in some subtypes of T-cell lymphomas. CD3 is a component protein of the T-cell receptor. As a CD3-bispecific antibody, ONO-4685 engages T-cells with malignant cells to induce anti-tumor activity. The drug is administered intravenously and is currently being evaluated in Phase 1 clinical trials.

Other names: Keyhole Limpet Hemocyanin + ONO-4685

Targets

CD3 (T-cell surface glycoprotein CD3)PDCD1 (Programmed cell death protein 1 receptor)

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