KH-CB19

KH-CB19 is a synthetic small molecule belonging to the indolecarboxylic acid derivatives class. It features a dichloro-substituted indole core with an (E)-2-amino-1-cyanoethenyl side chain and an ethyl carboxylate ester. The compound acts as a potent inhibitor of CDC-like kinases (CLKs), particularly dual specificity protein kinase CLK1. By inhibiting CLK family kinases involved in alternative pre-mRNA splicing regulation, KH-CB19 modulates splicing events implicated in cancer and neurodegenerative diseases. Structural studies have shown its binding to the kinase domain of human CLK1 and CLK3[4][6][7]. Preclinical research suggests anticancer activity through inhibition of cell proliferation and induction of apoptosis in cancer cell lines[4].

Other names

ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methylindole-2-carboxylateethyl 3-(2-amino-1-cyanovinyl)-6,7-dichloro-1-methyl-1H-indole-2-carboxylate