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**Khondrofen** is a marketed topical combination pharmaceutical from **Biosintez** formulated as an **ointment for external use** containing **chondroitin sulfate sodium, diclofenac sodium, and dimethyl sulfoxide**. It is positioned for musculoskeletal and joint disorders with pain and inflammation, combining a chondroprotective and cartilage-reparative component with a nonsteroidal anti-inflammatory drug and a penetration-enhancing/anti-inflammatory solvent component. The product's pharmacologic effect is described as being determined by its active ingredients: chondroitin sulfate supports cartilage matrix and connective tissue repair, diclofenac inhibits cyclooxygenase-mediated prostaglandin synthesis to reduce pain and inflammation, and dimethyl sulfoxide contributes local anti-inflammatory and transport-enhancing effects.
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