kifunensine

Kifunensine is a potent small molecule inhibitor of class I α-mannosidase enzymes, specifically targeting endoplasmic reticulum α-1,2-mannosidase I (MAN1B1) and Golgi mannosidases IA, IB, and IC. It was originally isolated from the actinobacterium Kitasatosporia kifunense. Kifunensine blocks the trimming of mannose residues from precursor glycoproteins in the endoplasmic reticulum, resulting in high-mannose glycoforms on N-linked glycoproteins. This property makes it widely used in cell culture to produce high-mannose glycoproteins for research purposes. Mechanistically, it acts as a competitive inhibitor with Ki values of 130 nM (endoplasmic reticulum) and 23 nM (Golgi). Kifunensine has shown potential therapeutic applications for sarcoglycanopathies and lysosomal storage disorders but is not approved for clinical use. It has also been studied as an immunoactive compound with effects on cell adhesion and protein processing[1][3][5].

Other names

kifunensineFR 900494FR900494FR-900494UNII-0NI8960271UNII0NI8960271UNII 0NI8960271