kigelia africana fruit extract

Kigelia africana fruit extract (KAE) is a botanical derivative obtained from the fruit of the African "sausage tree," a plant deeply rooted in traditional African medicine for treating skin-related conditions and infections. The extract is characterized by a rich profile of bioactive secondary metabolites, including naphthoquinones (such as lapachol), iridoids, and phenolic acids. In contemporary pharmacological research, KAE has demonstrated significant antineoplastic potential, particularly in colorectal carcinoma models, where it modulates signaling pathways associated with cell survival, apoptosis, and metastasis. It has been shown to suppress proteins linked to therapy resistance and exhibits synergistic cytotoxicity when combined with standard chemotherapeutic agents like cisplatin. Beyond oncology, the extract is widely utilized in the cosmetic and nutraceutical industries for its antioxidant, anti-inflammatory, and skin-firming properties.

Other names

sausage tree fruit extractKigelia pinnata fruit extract