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Kimara-F
- Development stage
- Unknown
- Lead developer
- Kims Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Kimara-F is an orally administered fixed-dose combination product developed by Kims Pharmaceutical for the treatment of rheumatoid arthritis. It combines leflunomide, a disease-modifying antirheumatic drug (DMARD) that inhibits mitochondrial dihydroorotate dehydrogenase (DHODH) to suppress pyrimidine synthesis and lymphocyte proliferation, with celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor that reduces prostaglandin synthesis to alleviate pain and inflammation. This combination aims to provide synergistic therapeutic benefits by simultaneously targeting the underlying autoimmune pathology and the associated inflammatory pain in patients with rheumatoid arthritis.
- Brand names
- Kimara-F키마라-F
- Other names
- leflunomide + celecoxibleflunomide + secoxib
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)DHODH (Dihydroorotate dehydrogenase (quinone), mitochondrial)Tyrosine kinase
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