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kinetin riboside
- Development stage
- Preclinical
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- In Vitro, Research Use (no Clinical Or Approved Route Established)
01
Overview
Kinetin riboside is a **synthetic nucleoside analog** derived from kinetin, a type of plant cytokinin. It functions as an **anticancer nucleoside** and research compound. Mechanistically, kinetin riboside has been shown to induce **apoptosis** and **cell-cycle arrest** in multiple myeloma and other tumor cell lines, mainly through caspase-9 cleavage and repression of cyclin D1 (CCND1) and cyclin D2 (CCND2) expression. Kinetin riboside also upregulates repressor isoforms of cAMP response element modulator (CREM), affecting cAMP-dependent transcription pathways[1][6][10]. Additionally, kinetin riboside triphosphate acts as an **ATP-neosubstrate for PTEN-induced putative kinase 1 (PINK1)**, independent of mitochondrial depolarization, suggesting a role in activating PINK1 signaling pathways, which is of interest in neurodegenerative disease research, particularly Parkinson's disease[5][7].
- Other names
- 6-Furfurylaminopurine ribosideN6-(2-Furanylmethyl)adenosineN6-FurfuryladenosineN-6-FurfuryladenosineN 6-FurfuryladenosineAdenosine, N-(2-furanylmethyl)-
02
Targets
CCND2 (Cyclin D2)CCND1 (Cyclin D1)PINK1 (PTEN-induced kinase 1)
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