Drug intelligence / Profile preview

KizaVie (LEAF4Life)

Development stage
Unknown
Lead developer
LEAF4Life
Modality
Nanoparticles → Drug Delivery Systems
Administration
Intravenous
01

Overview

KizaVie is a liposomal transcrocetin drug product developed by LEAF4Life for acute respiratory distress syndrome. It is an intravenous nanomedicine formulation that encapsulates transcrocetin in liposomes to prolong systemic exposure and provide sustained release relative to free transcrocetin. The intended pharmacology is to enhance oxygen diffusion in hypoxic tissues and microcirculation, with associated anti-inflammatory and tissue-protective effects, making it a supportive treatment candidate for moderate to severe ARDS. Clinical information provided indicates prior Phase 1 and Phase 2 experience, a favorable early safety profile, and ongoing Phase 3 registrational evaluation in combination with standard of care.

Brand names
KizaVie
Other names
liposomal transcrocetinliposomal trans-crocetin

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