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KJ-C2112
- Development stage
- Preclinical
- Lead developer
- CARsgen Therapeutics
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
KJ-C2112 is an investigational chimeric antigen receptor (CAR) T-cell therapy being developed by CARsgen Therapeutics, with initial development originating from Shanghai Jiao Tong University. This biologic therapy is engineered to dual-target both the wild-type Epidermal Growth Factor Receptor (EGFR, ErbB1) and its tumor-specific variant III (EGFRvIII). By expressing these specific CARs, the patient's T cells are redirected to identify and eliminate malignant cells overexpressing these receptors. EGFR and EGFRvIII are frequently implicated in the progression of various solid tumors, particularly glioblastoma and other epithelial-derived cancers. KJ-C2112 is currently in the preclinical stage of development, representing a targeted immunotherapy approach aimed at addressing cancers with high EGFR expression or specific mutations.
- Other names
- CAR-EGFR/EGFRvIII
02
Targets
EGFR (Epidermal growth factor receptor)EGFRvIII (Epidermal growth factor receptor variant III)
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