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KJ-C2527 (Kaixing Life Science)
- Development stage
- Preclinical
- Lead developer
- CARsgen Therapeutics
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
KJ-C2527 is an investigational allogeneic chimeric antigen receptor (CAR) T-cell therapy developed by Kaixing Life Technology, a subsidiary of CarsGen Therapeutics. It is designed to target Claudin18.2 (CLDN18.2), a tight junction protein that is frequently overexpressed in gastric and gastroesophageal junction cancers while maintaining restricted expression in normal tissues. As an allogeneic or "off-the-shelf" therapy, KJ-C2527 is derived from healthy donor T cells rather than the patient's own cells, which potentially allows for more rapid treatment delivery and reduced manufacturing costs compared to autologous CAR-T therapies. The therapy involves engineering these donor T cells to express a CAR specific to CLDN18.2, enabling them to recognize and eliminate tumor cells expressing the antigen. It is currently in preclinical development for the treatment of gastric cancer.
- Other names
- Claudin18.2-CAR-T cell therapy (allogeneic)
02
Targets
Claudin 18.2
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